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Ethics declarations All procedures complied with the standards for care and use of animal subjects as stated in the Guide for the Care and Use of Laboratory Animals (Institute of Laboratory Resources, National Academy of Sciences, Bethesda, MD)

However, the antitumor effect of monotherapy still cannot satisfy the therapeutic needs due to the disadvantages of TME, such as severe hypoxia condition and overexpressed GSH

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If identified, B12 injections can be part of a treatment plan designed to enhance energy levels and overall quality of life

Hydroxocobalamin is also naturally present in food sources and is considered highly effective, particularly for individuals with absorption difficulties or severe deficiency requiring rapid correction