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Using this model, it was found that a high-fat diet could aggravate the ferroptosis process and, together with ER stress, worsen the development of pancreatitis

Concentration-response binding and signalling data were analysed using the one-site binding inhibition and the three-parameter logistic equations in Graphpad prism, respectively

Gene expression analysis shows 14 antioxidant genes upregulated and 2 pro-oxidant genes suppressed, creating comprehensive antioxidant enhancement at the transcriptional level