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Trends Biochem Sci 30:325333 Flentjar NJ, Crack PJ, Boyd R, Malin M, de Haan JB, Hertzog P, Kola I, Iannello R (2002) Mice lacking glutathione peroxidase-1 activity show increased tunel staining and an accelerated inflammatory response in brain following a cold-induced injury

Thus, the two major products may need to be produced independently and in different quantities