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miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia-reperfusion injury in steatotic grafts

The increased infiltration of M1-type macrophages, T cells, and other cells activates the NLRP3 inflammasome by secreting pro-inflammatory factors like IL-1 and IL-6, promoting the maturation and release of IL-1 and IL-18, thereby driving pulmonary vascular remodeling (Xu et al., 2021

2023;18:e0280483

Altogether, this analysis suggests a previously unreported, temperature/additive-dependent association between stored RBC hemolysis and amino acid levels or adenylate/guanylate cyclase activities

CRP and NLR are markers of systemic inflammation broadly, and their trajectory during follow-up may reflect resolution of infections, alcohol abstinence, or other standard-of-care interventions rather than a direct antioxidant effect of glutathione