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Where These Numbers Come From The landmark Phase II trial (TIPO-1) tested three doses against placebo over 24 weeks with a controlled diet: The jump from 0.25 mg to 0.5 mg was substantial (nearly double), while 0.5 mg to 1.0 mg gained only 1.5 percentage points with far more side effects

Clean vials, consistent potency, reliable shipping

Jin L, Jiang Q, Huang H, Zhou X (2024) Topical histone deacetylase inhibitor remetinostat improves IMQ-induced psoriatic dermatitis via suppressing dendritic cell maturation and keratinocyte differentiation and inflammation

Yes, though the transition requires careful planning

GLP-1s as an accelerant, not a shortcut