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The underlying mechanism for halotolerance has been reported to be associated with the presence of a relatively large number of negatively charged residues (aspartate and glutamate) on the solvent-exposed surfaces of GtGGT and BsGGT structures even at high salt concentrations resulting in increased water binding capacity, thus increasing solvation of the protein and preventing self-aggregation

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Drugs R D 6:5355

Results IKE inhibits the xCT transporter activity and decreases the viability of HCT-116 cells SRB test was performed to determine the effect of xCT transporter inhibitor IKE on cell viability in the concentration range of 10-4000 nM, which targets glutathione inhibition applied for 48 h in HCT-116 CRC cells