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[1] The medication is generally given for at least 24 hours

After intense negotiation, Novartis offered an outcome-based scheme and significantly lower NHS price, and NICE gave positive guidance under an Innovative Medicines Fund pathway

Further reciprocal mutagenesis studies will be required to identify key interactions responsible for the contrasting effects of exendin-phe1, exendin-asp3 and other analogs, facilitating future design of agonists with even greater selectivity