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In age-related diseases and more particularly in IPF, mice treated with FOXO4-DRI display less senescent cells leading to a reduction of the progression of fibrosis 28

Cuomo, J., Appendino, G., Dern, A.S., Schneider, E., McKinnon, T.P., Brown, M.J., Togni, S

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A reduction in inhibition in the thalamus would therefore reduce inhibitory control of the thalamocortical relay cells, resulting in an increase in cortical excitability