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The search included terms such as small molecule GLP-1 receptor agonists, oral GLP-1 receptor agonists, Danuglipron, Orforglipron, and Aleniglipron. Additionally, information on ongoing clinical trials involving small molecule GLP-1 receptor agonists was retrieved from the ClinicalTrials.gov database using the same keywords

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Extended Data Figure 8 Effects of the PAM binding pocket mutations on potency of compound 2

Most patients see the earliest changes in the first few weeks, with fuller results building over two to three months of steady use

Kapoor carefully assess each patients unique health profile, including their response to previous treatments, to determine whether Mounjaro might be more effective for weight loss and metabolic health