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Nature Genetics

JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase

This may be due to copper's ability to enhance the expression of metalloproteinases (MMPs).16 MMPs normally regulate the degradation of collagen, and a specific one, MMP-1, may be responsible for the initiation of collagen fragmentation.17 Supporting this, a 2024 study noted that elevated MMP-1 levels appear to contribute to aging skin and that higher MMP-1 levels in mice led to:18 The loss and fragmentation of dermal collagen fibrils Contracted fibroblast morphology Reduced collagen production Increased expression of pro-inflammatory mediators Additionally, a 2016 study found that GHK-Cu significantly increased gene expression of MMP-1 and MMP-2 at the lowest concentration, which the studys authors considered to be one of the reasons the peptide was able to increase collagen and elastin production.19 So, what this could ultimately mean is that using too much GHK-Cu (or other copper peptides) may in theory increase the skins MMP-1 concentration above the levels involved in healthy collagen production, taking it into the collagen fragmentation and breakdown territory seen in older skin with naturally higher MMP-1 levels

doi: 10.3389/fphar.2024.1439536 Received 13 June 2024 Accepted 19 September 2024 Published 08 October 2024 Volume 15 - 2024 Edited by Karim Hosni, Institut National de Recherche et d'Analyse Physico-Chimique (INRAP), Tunisia Reviewed by Lourdes Franco, Faculty of Medicine.University of Extremadura, Spain Jolanta Orze-Gryglewska, University of Gdansk, Poland Updates Copyright 2024 Mu, Qu, Yin, Wang, Liu and Liu

[ref] Laundry detergents and fabric softeners: Laundry products are notorious for fragrances that trigger MCS symptoms