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57 and Cia et al

DOI: 10.3390/biomedicines9020130 35

The recommendations above are based on cyanocobalamin supplements

In this process, 5,10-methylene THF play a critical role in methionine regeneration and methyl donation, meanwhile MTHFR catalyzes the irreversible conversion of 5,10-methylene THF to 5-methyl THF that participate in generation of SAM in methionine cycle and offer methyl group 23