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A preclinical safety evaluation published in ScienceDirect confirmed that BPC-157 showed no test-related toxicity in single-dose and repeated-dose studies across mice, rats, rabbits, and dogs, with no genetic or embryo-fetal toxicity detected

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Loss of mtGSH disrupts m, promotes MOMP, and activates intrinsic apoptotic signaling, whereas restoration of mtGSH via GSH ester supplementation suppresses apoptosis 38,40