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Narrative reviews, conference abstracts, non-English articles, and studies lacking mechanistic investigation were excluded from this review

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An indirect comparison of data by Novo Nordisk from the STEP 1 trial and the SCALE trial of daily GLP-1 agonist liraglutide suggested 5.81% more weight loss with semaglutide than liraglutide at 68 weeks, and this was backed up by data from the STEP 8 trial, which directly compared the two treatments[1,3,4]

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