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LEfSe is known to reduce false positives and can highlight biological consistency across subclasses, while the KruskalWallis test used alone can achieve a lower false-negative rate compared to LEfSe 38

2a, b), indicating that these interactions do not have a role in cell surface delivery

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Serum metabolomic studies, including some described in the prior sections, identified lipid metabolite clusters associated with TBI at 24 h [30, 31, 47] and 4 days [30] after injury using sera from TBI and control patients ( Table 2)