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Out of these cytokines, TNF- is a major mediator of inflammation regulated by activation of a transcription factor known as Nuclear Factor-B (NF-B)

(2) DHODH: DHODH is a mitochondrial flavoprotein localized to the inner mitochondrial membrane, where it catalyzes the fourth and rate-limiting step of de novo pyrimidine biosynthesisthe oxidation of dihydroorotate to orotate 42,43

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Regulation of p53 downstream genes

Discussion The present study reported that the use of a combination of nutraceutical compounds, specifically acetyl-L-carnitine, L-carnitine, L-ARG and NAC, was effective in reducing IR and in improving insulin sensitivity and HIE in obese PCOS patients