The design bet behind a GLP-1/glucagon dual agonist is that GLP-1s insulinotropic, appetite-suppressing, glucose-lowering effects can be used to offset the hyperglycemic tendency of glucagon, while glucagons thermogenic and hepatic-lipid effects add weight-loss and liver-directed benefits that GLP-1 alone does not deliver
To safely take Vitamin B12 and folic acid together, patients should: Ask their oncologist before starting any supplements Tell their doctor about all current meds and supplements Stick to the recommended doses By working with their healthcare team, cancer patients can make smart choices about supplements
Abdominal distension, or swelling Abdominal pain Burping (eructation) Constipation Diarrhea Dizziness Dyspepsia, or upset stomach Fatigue Gas (flatulence) Gastroenteritis Gastroesophageal reflux disease (GERD) Hair loss Headache Heartburn Hypoglycemia Nausea Vomiting These side effects may appear mild at first, but they can escalate in severity or because of symptoms of more serious side effects
The same general technique applies
J Cell Biol 161(6):11631177 Fantin A et al (2013) NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis
