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Conflicts of Interest The authors declare no conflict of interest

10.2165/00023210-200115040-00004 CNS Drugs 97 YaoJ

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These ROS are generated at the mitochondrial level during oxidative phosphorylation by the activation of oxidase enzymes involved in signaling processes and by neurochemical reactions regulated by Cu(I) and Fe(II) ions in the Fenton and Haber-Weiss reactions

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