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It also has a direct effect on the heart and endothelial cells, preventing the progression of atherosclerosis through mechanisms such as increasing nitric oxide and decreasing endothelin-1, reactive oxygen species, and inflammatory cytokines

N Engl J Med 377(12):11191131

This triagonism distinguishes it from existing therapies such as semaglutide and tirzepatide, which focus on single or dual receptor pathways

This flexibility, combined with lower out-of-pocket costscompounded semaglutide starts at just $189 per month with PlexusDxmakes compounded options accessible to a broader population seeking evidence-based weight loss therapy

(2026, March 9)