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20262028 could be a big turning point for metabolic medicine

All experiments were performed in male mice between 26 and 36 weeks of age

These medications are manufactured and distributed by the company AstraZeneca

Larger molecules, such as exopolysaccharides (EPSs), and neurotransmitters, including serotonin, GABA, acetylcholine, and noradrenaline, cannot cross the BBB, but they can impact enteric neurons and the vagus nerve, thus indirectly modulating CNS function

Accordingly, whereas PPAR agonists (fibrates) are classically assumed to improve lipid and cholesterol metabolism via their action on the liver, agonists at PPAR (thiazolidinediones) are assumed to improve insulin sensitivity by enhancing adipose tissue differentiation and fatty acid uptake 10,11,23