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Although polymorphisms of the 2-adrenergic receptor especially, at amino acids 16 and 27, have been associated with more-active asthma and impaired -agonist treatment responsiveness, this comprehensive genotypic analysis has shown that the rare adrenoceptor 2 gene (ADRB2) variants Ile164 and -376ins are associated with severe adverse events during LABA therapy

Rheumatology 61 , 45214534 (2022)