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sulfonylureas and insulin may require dose reduction to prevent hypoglycemia when initiating a potent incretin-based agent Discuss realistic titration timelines: patients should understand that therapeutic weight loss at the target dose takes 12 to 20 weeks to become fully apparent Monitoring During Therapy Recheck HbA1c and fasting glucose at 8 and 16 weeks during titration if the patient has type 2 diabetes, as insulin or sulfonylurea doses may need downward adjustment

These usually happen when starting the medicine and often go away over time

Factors to consider include those in the list below

doi:10.3389/fendo.2021.767314

discontinuation leads to rapid weight regain