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Protein-containing fractions were pooled and loaded on a 1 ml Mono-Q column

Hypersensitivity reactions were also observed in a small percentage of subjects, affecting approximately 2-4% of participants in most studies [37]

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Diabetes causes the BBB leakage via downregulation of tight junction proteins, leading to dysfunctions of endothelial cells, pericytes, astrocytes, microglia, NG2-glia, and oligodendrocytes