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HlaisSAbou ReslanDRSarieddineHKNasreddineLTaanGAzarSet al

Conclusions The antagonistic pleiotropy in the function of the insulin/IGF-1 pathway reveals a paradox of the aging process since insulin/IGF-1 signaling is an important signaling pathway of growth and differentiation during development but its function accelerates the aging process later in the lifespan

They modulate key inflammatory responses and pathways like NF-kB, TNF-, and IL-6, which actively reduce swelling, stiffness, and discomfort

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Importantly, sdLDL is associated with increased triglyceride levels and low HDL-C, which is referred to as the lipid triad, a phenotype common in insulin resistance