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Beyond altering the permeability of the BBB, acrylamide disrupts multiple lipid metabolic pathways, including cholesterol, arachidonic acid, sphingolipid, and phospholipid metabolism, mainly through the dysregulation of upstream PPAR signaling, which is heavily involved in lipid metabolism (74)
In this state, L-dopa treatment in the MPTP model of PD augments homocysteine neurotoxicity without a reduction in the number of dopaminergic neurons (Bhattacharjee et al
This is the most comprehensive synthesis, combining clinical outcomes with mechanistic insights across 13 key nutritional supplements in PCOS management
It is linked to obesity and cardiometabolic diseases
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