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As discussed before in this manuscript, BBB breakdown is considered to be the basic pathophysiology of HT, and BBBP is directly correlated with the appearance of subsequent HT, suggesting that the assessment of the BBB permeability should be the most promising predictor of HT (154)

Research finds that IV, inhalation, and intranasal ingestion are the best methods for increasing systemic levels

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The combined use of these agents may have the potential for additive side effects, such as hypertensive crisis or cardiac arrhythmias

But robust, high-quality evidence for durable cosmetic skin-lightening from IV glutathione is lacking, and the FDA has not approved glutathione for skin lightening