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TB-500 and Post-Exertional Malaise Post-exertional malaise (PEM) the hallmark feature of ME/CFS-like long COVID is characterised by a disproportionate worsening of symptoms after physical or cognitive exertion

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Although the phosphorylated eIF2 inhibits the activity of its own guanine nucleotide exchange factor, this leads to the reduction of global rates of protein synthesis (Baird and Wek 2012)