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Nevertheless, the relationships between IGFs and numerous microenvironmental components, such as NK cells, neutrophils and even the microbiota, remain to be elucidated and incorporating other targets or combination therapies to address the individual and tissue heterogeneity of tumors is crucial

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Briefly, rat was anesthetized using isoflurane inhalation, and then the skin and subcutaneous tissue over the right knee joint were incised to expose the joint cavity

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