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Besides podocytes, berberine can also upregulate the expression of CPT1 and PPAR in renal TECs, further improving mitochondrial FAO and reducing lipid accumulation in DKD mice (Rong et al., 2021)

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The combination may be particularly valuable for complex rib injuries involving multiple fractures or significant soft tissue damage

The 2024 systematic review in the American Journal of Clinical Dermatology found most retinoin alternatives had comparable or slightly lower efficacy but better tolerability profiles

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