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Commonly in EEG slow-wave assays, hypoxia stress tests, and neuronal-culture resilience studies

Qiang X, Yang W-L, Wu R, Zhou M, Jacob A, Dong W, et al

Nuclei were labeled with DAPI staining (blue)

When adverse effects do occur following high-dose B12 administration, they are typically mild, transient, and often related to the route of administration rather than the vitamin itself

Interestingly, in pancreatic ductal adenocarcinoma (PDAC), uncoupling protein 2 (UCP2) can transport the aspartate derived from glutamine metabolism from mitochondria to the cytoplasm to generate NADPH, and silencing UCP2 can significantly inhibit the growth of PDAC