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Glutathione-S-transferase-theta genotypes and the risk of cyclophosphamide toxicity in dogs

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A novel enzyme (the bifunctional glutathione synthetase encoded by gshF ) that possessed both -GCS and GS activities and was non-sensitive to GSH was discovered in several microorganisms, including Streptococcus agalactiae [10], Enterococcus faecalis [10], Listeria monocytogenes [11], and Streptococcus thermophiles [12]

Furthermore, it appeared to have negative impacts on the gut microbiome, reducing abundance of healthy gut bacteria, decreasing short-chain fatty acid production, and increasing (alkalinizing) stool pH