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Study participants included in one or more analyses had been enrolled in selected insurance plans or health systems for at least one year, were free of at least one outcome at baseline, completed a minimum number of follow-up assessments, and either: 1) filled multiple extended-release/long-acting opioid analgesic prescriptions during a 90 day period (n=978)

The cycle turns over many times a day in active tissues

Alsubhi S, Osterman B, Chrestian N, Dubeau F, Buhas D, Srour M

VoldenJSmithIMSzatmariPBrysonSFombonneEMirendaPet al

24,25,28 The L-cells apical surface faces the gut lumen, allowing direct contact with nutrients