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Qsymia has demonstrated overall efficacy for weight loss maintenance, achieving sustained weight loss of 9-10% at the 108-week mark compared to 1.8% for placebo [67]

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Its worth being clear-eyed about the studys limits: it was a single-center, retrospective chart review, not a randomized trial, and nearly a third of patients discontinued the medication, most often due to gastrointestinal side effects