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The Arabidopsis tt19 -4 mutant differentially accumulates proanthocyanidin and anthocyanin through a 3 amino acid substitution in glutathione S -transferase

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The collapse of both astrocyte and microglia into pro-inflammatory states due to depletion of GSH, leading to sustained neuroinflammation and oxidative stress, is observed in many neurodegenerative diseases (Figure 2)