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Dosage strength is perhaps the most direct cost driver: higher concentrations require more active pharmaceutical ingredient per unit, which increases manufacturing and compounding expenses

The rapid resolution of symptoms prior to substantial weight loss supported a pharmacologic rather than metabolic effect

Patients may discontinue treatment due to the inability to tolerate these side effects

Glutathione: systemic protectant against oxidative stress and free radical damage

Short-term studies of up to 7 days have found that L-citrulline malate supplementation improves skeletal muscle metabolism and that the combination of L-citrulline and reduced glutathione (GSH) boosts plasma levels of L-citrulline, L-arginine and nitric oxide metabolites compounds that support muscle mass