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The timing differential is why sequential dosing (Semax first, Selank 3045 minutes later) creates stronger synergy than simultaneous administrationSemax establishes cholinergic tone before Selank amplifies it through GABA receptor modulation

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This pharmacological profile creates a dose-dependent weight loss curve that, in clinical trials, reached 24.2% at the 12mg weekly dose over 48 weeks and an astonishing 28.7% at 12mg over 68 weeks in the TRIUMPH-4 phase 3 trial