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It is produced naturally in every cell in the human body, with particularly high concentrations in the liver, where it plays a central role in detoxification

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However, there were no specific tools used to measure these improvements

Nrf2 depletion in macrophages leads to increased foam cell formation, increases the M1 inflammatory phenotype with enhanced expression of pro-inflammatory monocyte chemoattractant protein-1 and interleukin-6, and aggravates atherosclerosis (244, 245)

ROS can modify sperm proteins, leading to structural changes that impair motility, metabolic processes, and the sperms ability to bind to the oocyte