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The escalation ladder commonly looks like this: weeks 1 through 4 at 2mg, weeks 5 through 8 at 4mg, weeks 9 through 12 at 6mg, then continuing at 6 to 8mg for researchers who tolerate the escalation well

Along the same line, accumulating evidence is drastically scaling back the supposed role of ACE2 upregulation by renin-angiotensin inhibitors in COVID-19 severity (Verdecchia et al., 2020)

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doi: 10.7717/peerj.12467 42 LamichhaneSMoJSSharmaGChoiTYChaeSC