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Here are some key trends in GLP-1 indications and the landmark studies behind them: Type 2 Diabetes Mellitus (T2DM): The foundational indication for GLP-1s, with extensive evidence from trials like LEADER (liraglutide), SUSTAIN-6 (semaglutide), and HARMONY Outcomes (albiglutide) demonstrating significant HbA1c reduction and cardiovascular benefits

Semaglutide has a similar gastrointestinal safety profile as other GLP-1 Ras (68,69)

Week 14: Rapid appetite suppression + increased energy expenditure Month 13: Fastest fat loss of any studied GLP-1 class Month 36: Largest body composition shifts in trials 4872 weeks: Average 2430% total body weight reduction Ask our San Ramon team about retatrutide availability at your consultation

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Mendel, Ph.D