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Higher levels of TrxR1 in the serum correlates with shortened overall survival in patients with non-small cell lung cancer (Chen et al., 2017)

Stronger oxidative stress is caused by H

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This has led to (1) the development of specific diagnostic tests such as the ajmaline challenge in Brugada syndrome [26] and QTc evaluation during stress test in long and short QT syndromes (LQTS, SQTS), and importantly (2) the continued exploration and development of mechanism-based therapeutic approaches such as late sodium channel block in LQT3 [27] and the use of flecainide in catecholaminergic polymorphic ventricular tachycardia (CPVT) [28] which have already partially entered the clinical guidelines [29]