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The molecular mechanisms of the HBD of IGFBP-2 needs to be determined, but the HBD is implicated in downregulating PTEN expression and activates IGF-I signaling pathway in osteoblasts, indicating that the effect of the HBD on bone acquisition is in part mediated by the reduction of PTEN expression in osteoblastic cells

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AIM2, a newly discovered sensor, is capable of recognizing pathogens, such as HSV-1 or Francisella tularensis, as well as cytosolic dsDNA released upon cell damage [80]

Studies report levels of approximately 200 ng/mL in a 20-year-old individual, compared to about 80 ng/mL at age 60