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109 The TSC1/2 protein complex acts as a negative regulator of mTORC1, further emphasizing its role in controlling autophagy

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Immunotherapies appear such as the most valuable strategy and could lead to the emergence of a new type of senolytics in a near future

In some embodiments, mucoadhesive characteristics are also imparted to otic formulations disclosed herein, by incorporation of mucoadhesive carbomers, such as Carbopol 934P, to the composition (Majithiya et al., AAPS PharmSciTech (2006), 7(3), p

Building on this model, we integrate network pharmacology and graph theory to rank the therapeutic impact of DM2 DMTs, including metformin, on AD-related pathways within a DM2-AD comorbidity network (see Fig