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When MTHFR activity is reduced, 5-MTHF production falls methionine regeneration is impaired homocysteine accumulates folate is increasingly sequestered as 5,10-MTHF THF availability for nucleotide synthesis falls
Although the clinical trial results for Gln metabolism inhibitors have not been satisfactory thus far, a substantial body of prior research has provided a scientific foundation for investigating the targeting of tumor Gln metabolism
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