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Lean mass preservation Lean mass was relatively preserved across all dose tiers, though not perfectly

While severe hypoglycemia is uncommon with tirzepatide monotherapy due to its glucose-dependent mechanism, combining it with other glucose-lowering agents or supplements increases risk

Mayo Clinic explains that strength training helps maintain and build muscle, improve balance, and support everyday physical tasks. The American Cancer Society notes that strength training supports daily function, mobility, and overall physical health. Protecting muscle is not about appearance

While semaglutide and tirzepatide primarily reduce food intake through appetite suppression, retatrutide simultaneously increases energy expenditure

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