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Water retention: Temporary mild edema has been reported in IGF-1 interventions due to cell hydration effects

Patients taking semaglutide should expect some common side effects, including nausea, vomiting, diarrhea, and constipation

Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance

So more data is definitely needed, and there is likely varied impact based on diet and lifestyle behaviors during and after use

Clinical Eligibility Criteria PCPs Use to Evaluate GLP-1 Candidacy PCPs evaluate GLP-1 candidacy using evidence-based clinical criteria established by the American Diabetes Association, American Academy of Family Physicians, and specialty guidelines