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Clinical input provided by Valeria Marulanda, licensed medical provider at Perfect B in Doral, FL

[5] Djillani A, Pietri M, Moreno S, Heurteaux C, Mazella J, Borsotto M

BBR, Berberine

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chelation of the copper site by the thiol group, interference with the cellular transfer of tyrosinase to premelanosomes, which is the site of melanin synthesis and indirect inhibition of tyrosinase via its antioxidant effect as the free radical scavenging effect of it blocks the induction of tyrosinase activity caused by peroxides