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Hormone therapy is more appropriate in cases of severe hormone deficiency

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10,11 The ovaries are also made up of theca and granulosa cells, responsible for secreting estrogen, progesterone, androgens (male hormones), and other factors that regulate follicular activation and maturation

Tra i geni sovra-regolati ci sono quelli che codificano enzimi di riparazione del DNA (BRCA1, ATM), proteine della matrice extracellulare (COL1A1, COL3A1, ELN) e enzimi antiossidanti (SOD1, SOD2, GPX)