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Common signs include: Unexplained fatigue or weakness Low B12 reduces red blood cell production, leading to anaemia and persistent tiredness

If you experience persistent sleep problems after starting B12 supplements, consider adjusting the timing of your dose or consulting your GP or pharmacist to rule out other causes

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Instead, it is studied through several overlapping marker systems, including angiogenesis, nitric oxide signalling, VEGF related markers, fibroblast migration, collagen organisation, tendon fibroblast activity, inflammatory mediators and gastrointestinal mucosal models