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The deficiency was more severe than expected People with advanced B12 deficiency, especially with neurological symptoms, often feel rough at the start of treatment because the underlying problem was significant
View Source ORTHOP J SPORTS MED BPC-157 in Orthopaedic Sports Medicine Systematic Review 2025 Vasireddi N, Hahamyan H, Salata MJ, et al
It is important to distinguish between excessive supplementation and pathologically elevated B12 levels, which may indicate underlying haematological disorders, liver disease, or renal impairment rather than true overdose
Loren Pickart isolated it in 1973 while studying age-related changes in liver cell function
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