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This third mechanism adds a layer of GI disruption on top of the GLP-1-mediated delayed gastric emptying that both drugs share

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If you are doing really well and really need the GLP-1, whether it be for diabetes or weight loss or what have you, yes, there are medications that can mitigate some of the acid reflux, said Marzouk

Side effects associated with Rybelsus include: Digestive distress (nausea, abdominal pain, diarrhea, vomiting, constipation, heartburn, gastritis and GERD) Less common but more serious side effects include: Thyroid cancer Allergic reactions Kidney injury Gallstones Lowering the risk of Kidney Stones: A large trial compared different types of diabetes drugs with respect to the risk of kidney stones ( JAMA Internal Medicine , Jan