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The second receptor is GIP, or glucose-dependent insulinotropic polypeptide

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Delphinidin 3-rutinoside (D3R) through GPR40/120 and the Ca 2+ -calmodulin-stimulated protein kinase II (CaMKII) pathway activation stimulates GLP-1 secretion [189]

This phase IV clinical trial demonstrated that the combination of Sculptra (biostimulator) and Restylane products (hyaluronic acid fillers) delivered impressive results: Significant improvements in mid-face shape and contouring Enhanced skin quality, including significantly improving skin radiance and thickness Improved skin hydration maintained through follow-up visits High patient satisfaction, with 89% feeling more attractive and happier with their appearance The safety profile was excellent, with no treatment-related adverse events reported, confirming that these protocols are both effective and well-tolerated